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Despite the superior high ISO performance of the D300, there is still quite a gap between FX and DX in this area (high ISO performance), in particular @ ISO 3200+.
I am very sensitive to image noise, even images taken @ ISO 1600 with the D300 can be a worrying. However, I have no problem shooting @ ISO 6400 with my D700.
Images below are 1:1 cropped. Click image to view in detail.
Left: Nikon D300 @ISO1600; Right Nikon D700 @ISO1600
Left: Nikon D300 @ISO3200; Right Nikon D700 @ISO3200
Left: Nikon D300 @ISO6400; Right Nikon D700 @ISO6400
Left: Nikon D700 @ISO12800; Right Nikon D700 @ISO25600